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EURL ECVAM issues recommendation on three alternative-to-animal testing methods for carcinogenicity

21 marzo 2012

Joint Research Centre

On 14 March 2011, the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), hosted by the European Commission’s Joint Research Centre (JRC), issued a recommendation concerning three in vitro test methods for assessment of the carcinogenic potential of chemical substances. In conjunction with other available data, the test methods can be used to decide whether it is necessary to carry out animal testing for carcinogenicity (cancer bioassay) in the context of EU legislation.

They therefore have the potential to reduce and replace testing on animals. The three in vitro cell transformation assays (CTA), based on the use of cells originated from mouse and hamsters, model several stages of the cancer development process. The recommendation concludes that these methods can partially replace the currently used rodent carcinogenicity OECD Test Guidelines 451 and 453 which can lead to a reduction of laboratory animals and the time for toxicity testing needed.

EURL ECVAM’s study of the three test methods was peer reviewed by the EURL’s Scientific Advisory Committee (ESAC), and the recommendation underwent public consultation. The EURL ECVAM forwarded the results to the OECD for potential inclusion into the OECD Test Guidelines and subsequent international regulatory acceptance.

More information:

“Who’s who” in the field of alternative methods

30 noviembre 2008

We wish to remind you that, the DataBase on ALternative Methods (DB-ALM) of the Institute for Health and Consumer Protection (IHCP) to which ECVAM belongs to has made available for public access early this year the directory on contact details of :

“Persons & Institutions active in the Field of Alternative Methods.”

If you haven’t taken the opportunity yet to access the above data sector, you can do so by subscribing free of charge on the DB-ALM*. Select afterwards the “In Vitro Method” search option on the top menu bar.

The current data sector includes all persons which have confirmed/updated their data on our request, in addition to the contact details for the INVITTOX protocols and contains in total almost 200 entries. We wish to inform you that, in the future, we will contact all persons every 2 years in an automatic manner to verify and/or review their data. Those who don’t reply after two reminders we will have to remove from the directory.

New inscriptions

To extend the availability of information on persons/institutions active in the field of alternative methods (“Who’s who”), we invite you to send a short alert to: stating your wish to become part of this service.

We will come soon back to you and submit you a predetermined form for completion.

We are looking forward to your collaboration.


European Commission – Joint Research Centre (EC-JRC)
Institute for Health & Consumer Protection (IHCP)
European Centre for the Validation of Alternative Methods (ECVAM)

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